Synthesis and Antimicrobial Activity of New Benzimidazole derivatives Bearing Five-Membered Heterocyclic Moieties

Authors

  • Ammar Ferman Abbood Department of Chemistry, College of Science, Mustansiriyah University, IRAQ. Department of Chemistry, Faculty of Science, Sultan Qaboos University, PO Box 36, Postal Code 123, Muscat, OMAN.
  • Ahmed M. Abdula Department of Chemistry, College of Science, Mustansiriyah University, IRAQ.
  • Ghosoun Laftaa Mohsen Department of Chemistry, College of Science, Mustansiriyah University, IRAQ.
  • Younis Baqi Department of Chemistry, Faculty of Science, Sultan Qaboos University, PO Box 36, Postal Code 123, Muscat, OMAN.

DOI:

https://doi.org/10.23851/mjs.v32i4.992

Keywords:

benzimidazol, pyrazoline, isoxazoline, antimicrobial

Abstract

A new series of 2-substituted-1H-benzimidazol as potentially antimicrobial agents were designed, synthesized and characterized by IR, 1H-NMR and Mass spectra. The synthesized compounds were in vitro screened against Escherichia coli, Klebsiella spp. (gram negative), Staphylococcus aureus, Staphylococcus epidermidis (gram positive) as well as Candida albicans. The in vitro biological evaluation revealed that some of the target compounds exerted good antimicrobial activity. Noticeably, compound 11 exhibited promising activity against Staphylococcus aureus and Klebseilla SPP at 1 mg/mL concentration.

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Published

2021-11-20

How to Cite

[1]
A. F. Abbood, A. M. Abdula, G. L. Mohsen, and Y. Baqi, “Synthesis and Antimicrobial Activity of New Benzimidazole derivatives Bearing Five-Membered Heterocyclic Moieties”, MJS, vol. 32, no. 4, pp. 26–33, Nov. 2021.

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Section

Chemical Science

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