the effect of ferric oxide nanoparticles on peroxidase and catalase enzyme activity in healthy human serum




ferric oxide nanoparticles, catalase, peroxidase


الخلاصه : تم في هذا البحث تحضير الدقائق النانويه لاوكسيد الحديد باستخدام طريقه محلول الهلام من حامض الاوليك .تم دراسه حجم الدقائق النانويه بواسطه مسح المجهر الالكتروني وتحليل الجاذبيه الحراريه .تم دراسة تاثير الدقائق النانويه لاوكسيد الحديد على فعاليه انزيم الكاتليز والبيروكسيديز . اظهرت النتائج ان للدقائق النانويه المحضره تاثير تثبيطي تنافسي على انزيم البيروكسيديز ولاتنافسي على الكاتليز . Abstract: In this work ferric oxide nanoparticles were prepared by sol-gel method from oleic acid .the size of nanoparticles were studied by Scanning electron microscopy (SEM) and Thermal gravimetric analysis (TGA).the effect of ferric oxide nanoparticles on catalase and peroxidase enzyme activity in healthy human serum were studied .the results showed that ferric nanparticles acted as competitive inhibitor with peroxidase and un competitive inhibitor with catalase enzyme .

Author Biography

shaemaa hadi abdulsada, almustansiryah university



References :

Fouda M., Elkholy B. "Characterization &evaluation of Nanosized α–Fe2O3 pigment synthesized using three different carboxylic acid,Adv. Met. Lett. 2013, 4(5): 347-353.

Orel V., Sherchenko A. ,Romanov A., Magnetic properties and antitumor effect of nanocomplex of ironoxide .J.Nanomed.Nanotech.Biology and Medicine . 2015.11(1)47-55.

Nadagouda M.N., Varma R.S. A greener synthesis of core (Fe,Cu) nanocrystals using aquase Vit.C .Growth Des.2007:2582-2587.

Siskova K.M., Straska J., Krizek M., Tucekj., Zboril R., Formation of zero valent iron nanoparticles mediated by amino acids .Procedia Environ.Sci.2013.18:809-817.

Sayyad A.S., Balakrishnan K., Kabbani A.T., Vajtai R., Ajayan P.M., Synthesis of iron nanoparticles from hemoglobin and myoglobin .Nano.2012:23

Lu W., Shen Y., Xie A., Zhang W., Green synthesis and characterization of Fe3O4 nanoparticles .J.Majn.Mater.2010:322:1828-1833.

Herrera –becerra R., Rius J.I., Zorrilla C., Tannin Biosynthesis of iron oxide nanoparticles .Appl.Phys.A.,2010:100(453-459).

Bharde A.,Wani A., Shouche Y., Joy P.A., Prasad B., Sastry M.,Bacterial aerobic synthesis of nanocrystalline magnetite .J.Am.Chem.Soc.2005:127(9326-9329)

Kaul R.K., Kumar P., Burmar U., Joshi P., Agrawal A., Raliya R., Tarafdar J.C., Magnesium and iron nanoparticles production using microorganism and various salts .Mater.Sci.Poland.2012:30(254-258)

Mahdavi M., Namvar F., Ahmad M. , Mohamad R., Green biosynthesis and characterization of magnetic iron oxide nanoparticles using seaweed (sargassum muticum)aquase extract .Molecules 2013:18(5954-5964)

Kumar B., Smita K., Cumbal L., Debut A., Biogenic synthesis of iron oxide nanoparticles for 2-arylbenzimidazole fabrication .J.Saudi.Chem.Soc.2014:18(364-369)

Venkateswarlu S., Natesh Kumar B., Prasad C.H., Venkateswarlu P., Jyothi N.V.V. , Bioinspired green synthesis of Fe3O4 spherical magnatic nanoparticles using syzygium cumini seed extract .Physica.B.2014:449(67-71)

Yunanto, A., Gunawan, P., Iskandar, I., & Suhartono, E. (2015). Effect of Antibitiotic Applications on Salivary Amylase and Catalase Kinetic Parameters on Neonatal at Risk of Sepsis In Vitro.International Journal of Toxicological and Pharmacological Research. 7(6);269-273.

Kodydková, J., Vávrová, L., Kocík, M., & Zak, A. Human

catalase, its polymorphisms, regulation and changes of its activity in

different diseases.Folia Biologica, (2014). 60(4), 153-167.

Miricescu, D., Greabu, M., Totan, A., Didilescu, A., & Rădulescu, R. The antioxidant potential of saliva: clinical significance in oral diseases.Therapeutics, Pharmacology and Clinical Toxicology, (2011). 15 (2):139-143.

Babusikova, E., Jesenak, M., Evinova, A., Banovcin, P., & Dobrota, D. Frequency of polymorphism-262 C/T in catalasegene and oxidative damage in Slovak children with bronchial asthma.Archivos de Bronconeumología (English Edition), (2013). 49(12), 507-512.

Moradi M., Eftekhari M., and Tali A., Plasma selenium concentration and peroxidase activityin breast cancer patientsbefore and after chemotherapy ,I.J.C.P.. (2008)1(3)119-121.

MukhtarMBchB, L. D. R. S., & MuayadAbassFadhelMBchB, L. D

Impact Of Sustained Weight Loss Achieved Through Gastric

Gastric Sleeve Surgery With Circulating Level Of Obestatin Hormone In Iraqi Obese Subjects.IOSR Journal of Dental and Medical Sciences (IOSR-JDMS), .(2014).1(13), 54-60.

Abd S.T., Ali A.F. Effect of zinc oxide nanoparticles on total salivary peroxidase activity of human saliva .J.Baghdad College Dentistry. .(2015)27(2):178-182.

- Kamal Kolo, Kurt Konhauser , Wolfgang Elisabeth Krumbein Yves Van Ingelgem, AnnickHubin and PhilppeClaeys , Microbial dissolution of hematite and associated cellular fossilization by reduced iron phases , A study of ancient microbe-mineral surface interactions , Astrobiology(2009) ., 9 (8), ,.

-T.Shahwan,S.AbuSirriah,M.Nairat,E.Boyaci,A.E.Eroglu, T.B.Scott,andK.R.Hallam, Green synthesis of iron nanoparticles and their application as a fenton-like catalyst for the degradation of aqueous cationic and anionic dyes ,J.Chemical Engineering ,172, 258-266 , 2011.

- Sayan Bhattacharya , IndranilSaha , AniruddhaMukhopadhyay, Dhrvbajyot , ChattoPadhyay , Uday Chand Ghosh and DebashisChatterjee , Role of nano technology in water treatment and purification :potential applications and implications, Inter.J.ChemicalSci.and Technology., (2013)3 (3) ,59-64 ,.

-Xin Zhang, YouganNiu,XiangdongMeng,Yao Li and Jiupeng Zhao , structural evalution and characterstics of the phase transformations between α- Fe2O3 , Fe3O4 and γ Fe2O3 nanoparticles under reducing and oxidizing atmospheres " , J.Cryst.Eng.Comm., 15, 8166-8172 , 2013.

Xia X., Monterio R., and Riviere J., An index for characterization of nanoparticeles in biological system ,Nature Nanotechnology , (2010)5(9)671-675.




How to Cite

shaemaa hadi abdulsada, “the effect of ferric oxide nanoparticles on peroxidase and catalase enzyme activity in healthy human serum”, MJS, vol. 30, no. 1, pp. 75–79, Aug. 2019.



Chemical Science

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