Synthesis and Biological evaluation of some new 2-thioxoimidazolidin-4-one derivatives (part II)

Authors

  • Amjad Gali

DOI:

https://doi.org/10.23851/mjs.v29i1.111

Keywords:

thiosemicarbazone, chalcone, beta lactone, imidazolidin-4-one, antibacterial Activity.

Abstract

In the present work adifferent of new heterocyclic  compounds were synthesized by reaction of thiosemicarbazide with tow aldehydes (4-bromo benzaldehyde,2-chloro benzaldehyde). the reacting `of compounds(1,2)  with ethyl chloroacetate to give 3-[(arylidene)amino]-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one (3,4) which treating with defferent aldehydes togive chalcones  . the compound (3) reacted with ethyl aceto acetate to give ethyl 4-aryl-1-[(4-bromo benzylidene)amino]-6-oxo-2-sulfanyl-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole-5-carboxylate,and in series of reaction converted into a variety of derivatives. The prepared compounds were characterized by 1H NMR and FTIR spectroscopy.further more antibacterial activity of some the prepared  new cyclic compounds were evaluated against three types of bacteria

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Published

2018-10-31

How to Cite

[1]
A. Gali, “Synthesis and Biological evaluation of some new 2-thioxoimidazolidin-4-one derivatives (part II)”, MJS, vol. 29, no. 1, pp. 79–86, Oct. 2018.

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Chemical Science