Endothelin Level and Its Correlation with Uric Acid in Type 2 Diabetic Multiuse Patients

Authors

  • Zahraa Majid Ismail Chemistry Department, College of Science, Mustansiriyah University.
  • Zyad Hussein Jawad Chemistry Department, College of Science, Mustansiriyah University.
  • Ali Jasim Hammood Pharmacy Department, Al-Kut University College.

DOI:

https://doi.org/10.23851/mjs.v31i3.849

Keywords:

Endothelin (ET-1), Hypertension, Uric acid.

Abstract

This research aims to find the direct linkage among the Uric acid rates with Endothelin (ET-1), which is considered the indication of endothelial dysfunction or endothelial damage in patients with T2-DM. This study, included 96 patients with T2-DM and 96 controls, the mean age ranged (56.73 ± 9.14), (56.42 ± 8.74) respectively. Results showed a highly significant increase in Endothelin (ET-1) levels, uric acid, urea, and systolic blood pressure (SBP) was observed as compared with the control group, while Diastolic blood pressure (DBP) and body mass (BMI) were not substantially increased. Additionally, a significant positive correlation was found between ET-1 with uric acid, urea, SBP, DBP in patients with T2-DM (p < 0.05). Finally, elevated uric acid levels in older people who have chronic blood pressure are one of the factors influencing the increased release of ET-1, thus the development of cardiovascular disease.

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Published

2020-08-20

How to Cite

[1]
Z. M. Ismail, Z. H. Jawad, and A. J. Hammood, “Endothelin Level and Its Correlation with Uric Acid in Type 2 Diabetic Multiuse Patients”, Al-Mustansiriyah Journal of Science, vol. 31, no. 3, pp. 35–38, Aug. 2020.

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Section

Chemical Science