Endothelin Level and Its Correlation with Uric Acid in Type 2 Diabetic Multiuse Patients


  • Zahraa Majid Ismail Chemistry Department, College of Science, Mustansiriyah University.
  • Zyad Hussein Jawad Chemistry Department, College of Science, Mustansiriyah University.
  • Ali Jasim Hammood Pharmacy Department, Al-Kut University College.




Endothelin (ET-1), Hypertension, Uric acid.


This research aims to find the direct linkage among the Uric acid rates with Endothelin (ET-1), which is considered the indication of endothelial dysfunction or endothelial damage in patients with T2-DM. This study, included 96 patients with T2-DM and 96 controls, the mean age ranged (56.73 ± 9.14), (56.42 ± 8.74) respectively. Results showed a highly significant increase in Endothelin (ET-1) levels, uric acid, urea, and systolic blood pressure (SBP) was observed as compared with the control group, while Diastolic blood pressure (DBP) and body mass (BMI) were not substantially increased. Additionally, a significant positive correlation was found between ET-1 with uric acid, urea, SBP, DBP in patients with T2-DM (p < 0.05). Finally, elevated uric acid levels in older people who have chronic blood pressure are one of the factors influencing the increased release of ET-1, thus the development of cardiovascular disease.


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Kodama, S., Saito, K., Yachi, Y., Asumi, M., Sugawara, A., Totsuka, K., Saito, A. and Sone, H., 2009. Association between serum uric acid and development of type 2 diabetes. Diabetes care, 32(9), pp.1737-1742.

CrossRef | PubMed

Bennett, M., Pandya, BJ., and Krishnan, E., 2009. Hyperuricemia as an early marker for type 2 diabetes among young adults. Arthritis Rheum-Us. 60:2033.

Feig, D.I., Kang, D.H. and Johnson, R.J., 2008. Uric acid and cardiovascular risk. New England Journal of Medicine, 359(17), pp.1811-1821.

CrossRef | PubMed

Zoppini, G., Targher, G. and Bonora, E., 2011. The role of serum uric acid in cardiovascular disease in type 2 diabetic and non-diabetic subjects: a narrative review. Journal of endocrinological investigation, 34(11), pp.881-886.

CrossRef | PubMed

Khosla, U.M., Zharikov, S., Finch, J.L., Nakagawa, T., Roncal, C., Mu, W., Krotova, K., Block, E.R., Prabhakar, S. and Johnson, R.J., 2005. Hyperuricemia induces endothelial dysfunction. Kidney international, 67(5), pp.1739-1742.

CrossRef | PubMed

Lehto, S., Niskanen, L., Ronnemaa, T. and Laakso, M., 1998. Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke, 29(3), pp.635-639.

CrossRef | PubMed

Choi, Y.J., Yoon, Y., Lee, K.Y., Hien, T.T., Kang, K.W., Kim, K.C., Lee, J., Lee, M.Y., Lee, S.M., Kang, D.H. and Lee, B.H., 2014. Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. The FASEB Journal, 28(7), pp.3197-3204.

CrossRef | PubMed

Puddu, P., Puddu, G.M., Cravero, E., Vizioli, L. and Muscari, A., 2012. The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: molecular mechanisms and clinical implications. Journal of cardiology, 59(3), pp.235-242.

CrossRef | PubMed

Li, A., Yi, B., Liu, Y., Wang, J., Dai, Q., Huang, Y., Li, Y.C. and Zhang, H., 2019. Urinary NGAL and RBP Are Biomarkers of Normoalbuminuric Renal Insufficiency in Type 2 Diabetes Mellitus. Journal of immunology research, 2019.

CrossRef | PubMed

Fossati, P., and Prencipe, L., 1982. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clinical chemistry, 28(10), pp.2077-2080.

CrossRef | PubMed

Ruppersberg, H.S., Goebel, M.R., Kleinert, S.I., Wünsch, D., Trautwein, K. and Rabus, R., 2017. Photometric determination of ammonium and phosphate in seawater medium using a microplate reader. Journal of molecular microbiology and biotechnology, 27(2), pp.73-80.

CrossRef | PubMed

Dean, J., Dean, DA., Coloumbier, D., Brebdel, KA., Smith, DC., Burton, AH et al., Epi Info 6.04 c. A word processing, database, and statistic program for public health. Geneva, Switzerland: Center for Disease Control and Prevention (Atlanta, USA), and World Health Organization, (1997).

Haak, T., Jungmann, E., Felber, A., Hillmann, U. and Usadel, K.H., 1992. Increased Plasma Levels of Endothelin in Diabetic Patients With Hypertension: An Alternative Viewpoint. American journal of hypertension, 5(3), pp.161-166.

CrossRef | PubMed

Perfetto, F., Tarquini, R., Tapparini, L. and Tarquini, B., 1998. Influence of Non-Insulin-Dependent Diabetes Mellitus on Plasma Endothelin-1 Levels in Patients with Advanced Atherosclerosis. Journal of diabetes and its complications, 12(4), pp.187-192.


Tavares, A.M.V., Schaan, B.D.A., Terra, B.G., Duncan, B.B., Bavaresco, C.S., Leit?o, C.B., Silva, D.D.F.D., Amado, D.M., Souza, D.S., Bianchini, I.M. and Sousa, J.S., 2013. Estratégias para o cuidado da pessoa com doença crônica: diabetes mellitus.

Cheng, T.H., Lin, J.W., Chao, H.H., Chen, Y.L., Chen, C.H., Chan, P. and Liu, J.C., 2010. Uric acid activates extracellular signal-regulated kinases and the reafter Endothelin-1 expression in rat cardiac fibroblasts. International journal of cardiology, 139(1), pp.42-49.

CrossRef | PubMed

Mantovani, A., Rigolon, R., Pichiri, I., Morani, G., Bonapace, S., Dugo, C., Zoppini, G., Bonora, E. and Targher, G., 2017. Relation of elevated serum uric acid levels to first-degree heart block and other cardiac conduction defects in hospitalized patients with type 2 diabetes. Journal of Diabetes and its Complications, 31(12), pp.1691-1697.

CrossRef | PubMed


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Original Article

How to Cite

Z. M. Ismail, Z. H. Jawad, and A. J. Hammood, “Endothelin Level and Its Correlation with Uric Acid in Type 2 Diabetic Multiuse Patients”, Al-Mustansiriyah Journal of Science, vol. 31, no. 3, pp. 35–38, Aug. 2020, doi: 10.23851/mjs.v31i3.849.

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