Toxicity of Porous Silicon Nanoparticles on Liver of Mice

Kareem H. Jwaid; Majid S. Jabir; Uday M. Nayef

doi:10.23851/mjs.v28i3.552

Authors

Kareem H. Jwaid Departments of medical of engineering, University of Technology
Majid S. Jabir Departments of Applied Sciences biotechnology Branch, University of Technology
Uday M. Nayef 3Departments of Applied Sciences Laser Physics Branch, University of Technology

DOI:

https://doi.org/10.23851/mjs.v28i3.552

Keywords:

porous silicon nanoparticles, Toxicity, biochemical assay

Abstract

Nanoparticles are a special group of materials with unique features and extensive application in diverse fields. The present work demonstrates the toxicity impact of porous silicon nanoparticles (PSNPs) on kidney parameter which is prepared by electrochemical etching method. the synthesis of porous silicon nanoparticles are conformed by using structural and optical properties from through scanning electron microscope and atomic force microscopy techniques. The effect of toxicity of these nanoparticles on the liver parameters in laboratory animals use four groups each groups involve three duplicities was studied. Injected of porous silicon nanoparticles in the intraperitoneal at concentration of 1mg/kg. The results of biochemical assay Aspartate Amino-Transferase (GOT), Alanine Amino-Transferase (GPT), Alkaline Phosphatase (ALP) were compared with the control groups, for four weeks and then confirm a result was made with Histological study for section of liver. Results show no significant differences in levels (GOT, GPT, ALT) among the test groups via comparison with controls groups. This Result indicates no toxic effect of porous silicon nanoparticles' on kidney parameters.

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