Toxicity of Porous Silicon Nanoparticles on Liver of Mice


  • Kareem H. Jwaid Departments of medical of engineering, University of Technology
  • Majid S. Jabir Departments of Applied Sciences biotechnology Branch, University of Technology
  • Uday M. Nayef 3Departments of Applied Sciences Laser Physics Branch, University of Technology



porous silicon nanoparticles, Toxicity, biochemical assay


Nanoparticles are a special group of materials with unique features and extensive application in diverse fields. The present work demonstrates the toxicity impact of porous silicon nanoparticles (PSNPs) on kidney parameter which is prepared by electrochemical etching method. the synthesis of porous silicon nanoparticles are conformed by using structural and optical properties from through scanning electron microscope and atomic force microscopy techniques. The effect of toxicity of these nanoparticles on the liver parameters in laboratory animals use four groups each groups involve three duplicities was studied. Injected of porous silicon nanoparticles in the intraperitoneal at concentration of 1mg/kg. The results of biochemical assay Aspartate Amino-Transferase (GOT), Alanine Amino-Transferase (GPT), Alkaline Phosphatase (ALP) were compared with the control groups, for four weeks and then confirm a result was made with Histological study for section of liver. Results show no significant differences in levels (GOT, GPT, ALT) among the test groups via comparison with controls groups. This Result indicates no toxic effect of porous silicon nanoparticles' on kidney parameters.


Download data is not yet available.


Xie, J.; Lee, S. and Chen, X., Nanoparticle-based theranostic agents. Adv Drug Deliver Rev . Vol (62), 2010, pp 1064-1079.

Couvreur, P., Nanoparticles in drug delivery: past, present and future. Adv Drug Deliv . Vol( 65), 2013,pp21-23.

Choi, H. S.; Park, S.; Zhong, G. Renal clearance of quantum dots. Nature Biotech. Vol(25), 2007,PP1165-1170 .

Wang, R. B.; Billone, P. S., and Mullett, W. M., Nanomedicine in action: an overview of cancer nanomedicine on the market and in clinical trials. J. Nanomater .2013, PP 629-681.

Liu, Z.; Maniya, N. H.; Patel, S. R.,and Murthy, Z. V. P. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy .Proc. Natl Acad. Sci. USA. Vol (105), 2008, PP1410-1415.

Ballou, B.; Lagerholm, B. C.; Ernst, L.; Bruchez, M. P. and Waggoner, A. S. Noninvasive imaging of quantum dots in mice. Bioconjugate Chem . Vol(15), 2004,PP79-86.

Maniya, N. H.; Patel, S. R.; Murthy, Z. V. P., Electrochemical preparation of microstructured porous silicon layers for drug delivery applications. Super lattices and Microstructures. Vol ( 55), 2013, PP144-150.

Yang, G. .Laser Ablation in Liquids Principles and Applications in the Preparation of Nanomaterials, Singapore Pan Stanford Publishing, USA. 2012. PP240-248.

Kim, D.; Park, S.; Lee, J. H.; Jeong, Y. Y. and Jon, S. Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. J. Am. Chem. Soc. Vol(129), 2007, PP7661-7665.

Xie, G.; Sun, J.; Zhong, G.; Shi, L.; Zhang, D. Biodistribution and toxicity of intravenously administered silica nanoparticles in mice. Arch. Toxicol. Vol (84),2010,PP183–190.


Key Dates





Original Article

How to Cite

K. H. Jwaid, M. S. Jabir, and U. M. Nayef, “Toxicity of Porous Silicon Nanoparticles on Liver of Mice”, Al-Mustansiriyah Journal of Science, vol. 28, no. 3, pp. 209–213, Jul. 2018, doi: 10.23851/mjs.v28i3.552.

Similar Articles

1-10 of 86

You may also start an advanced similarity search for this article.