The Effects of Stress on the Vascular System for Different Ages in Rats


  • Mohanad A. Kassim Department of Biology, College of science, Mustansiriyah University



cardiovascular system, stress, maturation, hypertension, blood vessels.


The effects of stress in newborns were more severe than adults, The changes in the blood vessels and the heart of age-related and the result of stress are reflected on adaptation and resistance to the development of cardiovascular disease, such as hypertension. Therefore, experiments were conducted to study the changes developments on the heart and blood vessels under the influence of stress at the stages of maturity, used a laboratory rat model. The impact of each of the chronotropic and the stress on the blood vessels at the newborn rats were higher than adult animals, myocardial indolence and high blood pressure were observed at the old rats compared to adult animals as a result of the stress-responses.


Download data is not yet available.


Berdnikova V.A., Kuznocova Ya.V., Kuznecova A.S. Vascular and chronotropic effects of stress in rats of both sexes and age. Bulletin experimental biology and medicine. No.1:13–17. 2012

Clerico A., Fabio A. R., Passino C., Emdin M. Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications. Am J Physiol Heart Circ Physiol 290: H17–H29, 2006

Uchino B. N., Uno D., Holt-Lunstad J., Flinders J. B. Age-Related Differences in Cardiovascular Reactivity During Acute Psychological Stress in Men and Women. Journal of Gerontology: PSYCHOLOGICAL SCIENCES. 54B (6): 339-346. 1999

Boutcher S.H., Stocker D.J. Cardiovascular response of young and older males to mental challenge. Journal of Gerontology. B51: 261–267. 1996

Bulpitt C., Rajkumar С. Beckett N. Hypertension in the elderly Clinician’s manual. Published by Science Press, London. 1005–1015. 1999

Brandes R., Fleming I., Busse R. Endothelial aging .Cardiovascular Research. 66: 286–294. 2005

Grinene E.Yu., Vaytkavichus V.Yu., Marchinskene E.Yu. The particularities of heart beat in students in school. Physiology of human.16 (1): 89–93.1990

Godfrey K. M. and Barker D. JP. Fetal nutrition and adult disease.Am J Clin Nutr; 71(suppl):1344S–52S.2000

Golbidi S., Frisbee J. C., Laher I. Chronic stress impacts the cardiovascular system: animal models and clinical outcomes. American Journal of Physiology - Heart and Circulatory Physiology. 308 No.12.2015

Treiber F., Musante L., Kapuku G. Cardiovascular (CV) responsivity and recovery to acute stress and future CV functioning in youth with family histories of CV disease: a 4-year longitudinal study. International Psychophysiological Journal. 41: 65–74.2001

Simon C. Langley-Evans Developmental programming of health and disease. Proc Nutr Soc. 65(1): 97–105. 2006

WHO. Programming of chronic disease by impaired fetal nutrition Evidence and implications for policy and intervention strategies. 2002

Uchino B., Birmingham W., Berg C. Are older adults less or more physiologically reactive? A meta-analysis of age-related differences in cardiovascular reactivity to laboratory tasks. The Journals of Gerontology: Physiological Science. 65(2): 154–162.2010

Zicha J, Kune J. Ontogenetic aspects of hypertension development: analysis in the rat. Physiological Review.79: 1227–1282. 1999


Key Dates





Original Article

How to Cite

M. A. Kassim, “The Effects of Stress on the Vascular System for Different Ages in Rats”, Al-Mustansiriyah Journal of Science, vol. 28, no. 3, pp. 68–71, Jul. 2018, doi: 10.23851/mjs.v28i3.547.

Similar Articles

1-10 of 139

You may also start an advanced similarity search for this article.