To Study of Hepcidin Levels and Certain Hematological Parameters in Pregnant Women
DOI:
https://doi.org/10.23851/mjs.v28i3.545Keywords:
Hepcidin, Ferretin, Iron, hematological, Binding capacityAbstract
The present study was designed to find the relation between certain hematological parameters and pregnancy. The study used one hundred volunteers (seventy five pregnant women and twenty five non-pregnant women). Then, pregnant women divided into three subgroups according to the trimester (first trimester, second trimester and third trimester). Hematological tests showed significant increased (P<0.05) in TIBC (Total Iron Binding Capacity) and significant decreased (P<0.05) in Hepcidin, ferritin, Iron, Hb (hemoglobin) and MCV (mean corpuscular volume) compared with non-pregnant women group. Third trimester show a high affected according to the results compare with other trimesters. It was concluded from this study that the pregnancy led to several hematological parameters change.Downloads
References
Guo P, Cui R, Chang YZ, Wu WS, Qian ZM, Yoshida K, Qiao YT, Takeda S, Duan XL., "Hepcidin, an antimicrobial peptide is downregulated in ceruloplasmin-deficient mice," Peptides, vol. 30, pp. 262-266.
Hoppe M, Lönnerdal B, Hossain B, Olsson S, Nilsson F, Lundberg P A, Rödjer S, Hulthén L. "Hepcidin, interleukin-6 and hematological iron markers in males before and after heart surgery. J Nutr Biochem. 2009; 20: 11-16. ," Anal Biochem, vol. 384, pp. 245-253, 2009.
Bansal SS, Halket JM, Bomford A, Simpson RJ, Vasavda N, Thein SL, Hider RC "Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry," Anal Biochem, vol. 384, pp. 245-253, 2009.
T. Ganz, "Hepcidin—A regulator of intestinal iron absorption and iron recycling by macrophages," Clin. Haematol, vol. 18, pp. 171–182, 2005.
T Ganz, "Hepcidin and its role in regulating systemic iron metabolism," Am. Soc. Hematol. Educ. Progr, vol. 10, pp. 29-35, 2006.
E. Nemeth and T. Ganz, "Regulation of iron metabolism by hepcidin. ," Annu. Rev. Nutr. , vol. 26, pp. 323–342, 2006.
A.T. Murphy, D.R. Witcher, P. Luan, and V.J. Wroblewski, "Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. ," Blood , vol. 110, pp. 1048–1054, 2007.
HZW Grotto, "Metabolismo do ferro: uma revisão sobre os principais mecanismos envolvidos em sua homeostase. ," Rev Bras Hematol Hemoter, vol. 30, pp. 390-397, 2008.
Tjalsma H, Willems HL, Swinkels DW Kemna EH, "Hepcidin: from discovery to differential diagnosis. ," Haematologica, vol. 93, pp. 90-97, 2008.
Esparza AL, Núñez MT. Mena NP, "Regulation of transepithelial transport of iron by hepcidin. ," Bras J Med Biol Res, vol. 39, pp. 191-193, 2006.
Frazer DM, McLaren GD Anderson GJ, "Iron absorption and metabolism," Curr Opin Gastroenterol, vol. 24, pp. 129-135, 2009.
Roe MA, Collings R, Dainty JR, Swinkels DW, Fairweather-Tait SJ. "Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men. ," Am J Clin Nutr, vol. 89, pp. 1088-1091, 2009.
Trinder D, Ayonrinde OT, Olynyk JK, "HCV, iron, and oxidative stress: the new choregraphy of hepcidin. ," Gastroenterology, vol. 134, pp. 348-351, 2008.
Darshan D, Anderson GJ. "Interacting signals in the control of hepcidin expression. ," Biometals, vol. 22, pp. 77-87, 2009.
Nemeth E., "Iron regulation and erythrpoiesis," Curr Opin Hematol, vol. 2008, pp. 169-175, 2008.
Deicher R, Hörl WH, "New insights into the regulation of iron homeostasis," Eur J Clin Invest. , vol. 36, pp. 301-309, 2006.
M Rehu and K. and Ostland, V Punnonen, "maternal serum hepicidin is low at term and independent of cord blood iron state. ," J. Haematol, vol. 85, pp. 345-352, 2010.
S. Van Santen and Kroot J.J. and Swinkels D.W., "the iron regulatory hormone hepicidin is decreased in pregnancy. ," Clin. Chem. Lab. Med, vol. 51, pp. 1395-1401, 2013.
K. J. Schulze and P. and Ray, A. Christian, "Hepicidin and iron state among pregnant women in Bangladesh," Clin. Nutr, vol. 17, pp. 451-456, 2008.
Rafiean-Kopaie M. & Hamid N., "Impact of inflammation on anemia of hemodialysis patients who were under treatment of recombinant human erythropoietin. ," Renal Inj Prev, vol. 2, no. 3, pp. 93-95, 2013.
CN, Andrews N, "Anemia of inflammation, the hepcidin link," Curr Opin Hematol, vol. 12, pp. 107-111, 2005.
A. Finkenstedt . "Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy," Blood Cells Mol. Dis, vol. 48, pp. 233-237, 2012.
Domellöf M, "The diagnostic criteria for iron deficiency in infants should be reevaluated." Nutr, vol. 132, pp. 3680-3686, 2002.
N. Raza, Iram S., Bibi M., Muhammad A., Muhammad S. "of iron deficiency in pregnant women by determining iron status," Ayub Med Coll Abbottabad. , vol. 23, no. 2, pp. 36-40, 2011.
D. V. Bhale, Pramod V. B., Shubhangi A. M. and Sanjay G. "Study of Serum Ferritin Levels in Anemia of Pregnancy. ," Rec. Tre. Sci. Techno, vol. 9, no. 1, pp. 41-46, 2013.
Downloads
Key Dates
Published
Issue
Section
License
Articles accepted for publication in Al-Mustansiriyah Journal of Science (MJS) are protected under the Creative Commons Attribution 4.0 International License (CC BY-NC). Authors of accepted articles are requested to sign a copyright release form prior to their article being published. All authors must agree to the submission, sign copyright release forms, and agree to be included in any correspondence between MJS and the authors before submitting a work to MJS. For personal or educational use, permission is given without charge to print or create digital copies of all or portions of a MJS article. However, copies must not be produced or distributed for monetary gain. It is necessary to respect the copyright of any parts of this work that are not owned by MJS.
How to Cite
