Synthesis and Biological Evaluation of Some Pyrrolidine-2-one Derivatives


  • nadia azeez betti Materials engineering department, University of Technology
  • Redha Ib. Hussain Department of chemistry, Mustansiriyah University
  • Sahar Ab. Kadhem Department of chemistry, Mustansiriyah University



In this research a number of pyrrolidine-2-one derivatives were prepared by lactamization of γ –butyrolactone (GBL) with hydrazine hydrate (80%) to produce (1-aminopyrrolidine-2-one) that undergoes several reactions to afford these derivatives that diagnosed by infrared, nuclear magnetic resonance and mass spectroscopy. Antibacterial activity has also been studied using some types of bacteria, some were found to have good antibacterial activity.


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Author Biography

  • nadia azeez betti, Materials engineering department, University of Technology
    lecturer in materials department/university of technology-iraq


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Original Article

How to Cite

nadia azeez betti, R. I. Hussain, and S. A. Kadhem, “Synthesis and Biological Evaluation of Some Pyrrolidine-2-one Derivatives”, Al-Mustansiriyah Journal of Science, vol. 31, no. 1, pp. 31–40, Mar. 2020, doi: 10.23851/mjs.v31i1.743.