Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique


  • Faiq H. Saaid Department of Chemistry, College of Science, Salahaddin University.
  • Shatha J. Dawood Department of Chemistry, College of Science, Salahaddin University
  • Bushra H. Marbeen Department of Chemistry, College of Science, Salahaddin University.



1, 3, 4-oxadiazole, spectroscopic study, antibacterial activity, nitrogen, oxygen heterocyclic, synthesis.


In the present study, a new of 1,3,4-oxadizole derivatives(4a1,4a2,4b1,4b2) were synthesized using an ultrasonic technique. Benzohydrazine and its substituted (2a, 2b) were obtained from the reaction of hydrazin with benzoylchloride and its substituted (1a, 1b). Compounds (2a, 2b) react with chloroacetic acid to form compounds (3a,3b) which react with p-phenylene diamine and hydrazine in presence of DMSO as a solvent to obtain new compounds (4a1,4a2, 4b1,4b2) by ultrasonic technique. The structures of the synthesized compounds were elucidated by spectral data: infrared spectra (FT-IR) and 1HNMR and CHN analysis. The synthesis compounds (4b1, 4b2, 4a1, and 4a2) were evaluated for antibacterial (Staphylococcus1 aureus) by the serial dilution method


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How to Cite

F. H. Saaid, S. J. Dawood, and B. H. Marbeen, “Synthesis and Characterization of 1,3,4- oxadiazole Derivatives using an Ultrasonic Technique”, Al-Mustansiriyah Journal of Science, vol. 29, no. 2, pp. 101–105, Nov. 2018, doi: 10.23851/mjs.v29i2.183.

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