Investigation the level of IL-10 and IFN-γ in mice infected with Entamoeba histolytica and treated with earthworm powder

Nebrass Faleh Chachain, Hussein Ali Jamil, Shaima Dawood Salman

Abstract


This study was carried out to detect the effect of earthworm powder on the Entamoeba histolytica in white mice and to measure the serum of two cytokines (IFN-γ and IL-10) of infected and treated mice with earthworm powder in comparing with metronidazole drug after 3, 7 and 9 days. Result showed that the infected mice which treated with earthworm powder in a concentration of 200 mg/ml for 10 days the level of IFN-γ in serum was (170.67, 150.33 and 145.67 pg/ml) respectively compared with control group, in the earthworm powder group (none infected) level of IFN-γ after 3, 7, 9 days was (105.50, 121.50, 127.00 pg/ml) respectively, also in the metronidazole treatment group IFN-γ level after 3, 7, 9 days was (188.33, 263.50, 253.33 pg/ml) respectively compared to control group. In the treatment earthworm powder group level IL-10 after 3, 7, 9 days was (108.67, 105.67 and 103.17 pg/ml) respectively compared with control group, but in the earthworm powder group (none infected) level IL-10 after 3, 7, 9 days was (95.67, 95.83, 95.67 pg/ml) respectively, also in the metronidazole treatment group IL-10 level after 3, 7, 9 days was (109.83, 107.67, 103.33 pg/ml) respectively compared with control groups.

Keywords


Earthworm powder, Entamoeba histolytica, IFN-γ, IL-10

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References


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DOI: http://dx.doi.org/10.23851/mjs.v30i1.490

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