Incidence and relationship of obesity with serum ferritin , lipid profile, uric acid and urea at Obesity Medical Center in Iraq

Emad Mahmoud Eltayef

Abstract


Obesity is an excessive accumulation of energy in the form of body fat which impairs health. The main cause of obesity epidemic is clear: overeating, especially that of foods, which are rich in fats, extracted sugars or refined starches. This combined with decline in physical activity results in an imbalance of intake and expenditure of calories, resulting in excess weight and eventually obesity. Co-morbidities commonly associated with obesity include diabetes, cardiovascular and respiratory disease, dyslipidemia, degenerative joint disease, stress incontinence and some form of tumors and other various diseases. In clinical practice, serum ferritin is used as a screening tool to detect iron deficiency. However, its reliability in obesity has been questioned.
The objective of this study was to assess and compare the incidence of obesity , hyperferritinemia , hyperlipidemia and hypouricemia among middle aged hypertensive patients in the local setting as well as, to shed light on this issue, we have compared serum ferritin levels and other classical indices between obese males and females, finally to evaluate the main factors accounting for ferritin levels .This cross-sectional study was conducted at Obesity Medical Center at Al-Kindy Teaching Hospital, Baghdad, from January to march 2016. One hindered and nine patients seen in the medical outpatient center were enrolled in the study plus to participate of 61 subjects as control. On the basis of body mass index (BMI), 169 participants were divided into two groups: BMI 18.5–25 kg/m2 non obese (control), BMI ≥ 30 kg/m2 obese subjects.
The main demographic features data of the study population appeared that , SP and DP were significantly higher in obese patients (P<0.05) compared with control. Serum Hb was significantly lower in obese male when compared with the non-obese group and no difference in female group was observed. In addition, the levels of serum lipid profile and other studied parameters according to gender showed the following results: The mean levels of cholesterol, Tg, LDL, VLDL, glucose, ferritin had significantly higher in obese (for both genders) when compared with the non-obese group.

Dissimilarly, the mean concentration of HDL, uric acid, urea in obese groups had significantly lower when compared with the control in both genders.
The comparison results between obese males and females concluded that female subjects had significantly higher BMI, and lower in VLDL and ferritin levels compared to male subjects. Present study includes all types of correlation between parameters and appeared the following results:
It was observed a significant correlation between serum cholesterol levels and BMI (-0.637 ,p=0.048 ) , VLDL and age ( 0.876 ,p=0.001 ) ,uric acid and glucose (-0.686 ,p=0.028) ,urea and SP (0.778 ,P=0.008 ) ferritin and SP (0.709 ,P=0.022 ) in males group. As well as, a significant correlation in females group was found between cholesterol and HDL (-0.0665,P=0.036) ,cholesterol and BMI (0.724 ,P=0.018 ) ,urea and BMI (-0.633 , p=0.050 ) .In obese patients (n=109), stepwise linear regression analysis showed that, serum ferritin levels were independently correlated with LDL ,VLDL levels and age, (P< 0.001).

Keywords


Obesity, ferritin , lipid profile , Body Mass index , Obesity complications.

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DOI: http://dx.doi.org/10.23851/mjs.v29i1.228

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